Lecture by Roger Farrar, professor, Department of Kinesiology and Health Education, the University of Texas at Austin:
Macrophages are released from bone marrow in response to tissue injury. They are critical for breaking down protein debris subsequent to injury. Recently the inflammatory macrophages have been found to shift in their function, from breaking damage protein down to creating a regenerative cellular environment once the debris has cleared. Our laboratory has utilized pro-regenerative macrophages to enhance muscle repair by infusion of macrophages, alone, or in combination with stem cells. Both treatments have enhanced muscular tissue repair.